

George turns out to be playful, and Davis considers him his best friend. George frightens Pavo until Davis talks to him as well. Just then, an albino gorilla named George comes running in, which leads to Connor freaking out and upsetting Pavo, who runs after Connor until George knocks him over. Pavo is upset until Davis talks him down gently. They observe an ape named Pavo who attempts to find a female ape to mate with, but Davis splits them up. At an animal sanctuary in San Diego, primatologist Davis Okoye (Dwayne 'The Rock' Johnson) leads co-workers Nelson (PJ Byrne), Connor (Jack Quaid), and Amy (Breanne Hill) to an ape enclosure. The samples themselves fly away across the country.

She makes it to the escape pod and is released as the station blows up with the rat still inside, but the damage to the pod causes it to break open, depressurize, and explode, killing Kerry. Kerry goes back for the samples, and the rat monster chases her. Energyne's CEO Claire Wyden (Malin Akerman) orders Kerry to bring back the mutagen samples, or to not return at all. Kerry Atkins (Marley Shelton) is the sole survivor, and she is contacting the heads at Energyne (the ones who developed the CRISPR mutagen) to help her return. In the present day, aboard a space station, a lab rat has been mutated with CRISPR and has wiped out the entire crew. In 1993, a new piece of technology called CRISPR was developed and then quickly used to develop dangerous experiments. At night, one of the canisters crash-lands in George's habitat, and George is exposed to the pathogen. He has befriended a rare albino western lowland gorilla named George, having saved him from poachers, and communicates with George using sign language and hand gestures. Primatologist Davis Okoye, a former US Army Special Forces soldier and member of an anti-poaching unit, works at the San Diego Wildlife Sanctuary. The falling pieces leave a trail of debris across the United States, including the Everglades in Florida, where a canister is consumed by an American crocodile, and a forest in Wyoming, where a gray wolf is exposed to the pathogen. Atkins is able to flee in the escape pod when the station implodes, but due to damage from the rat it disintegrates upon re-entry, killing her. Kerry Atkins, the lone surviving crew member, is ordered by CEO Claire Wyden to retrieve research canisters containing a pathogen. Athena-1, a space station owned by gene manipulation company Energyne, is destroyed after a laboratory rat mutates and wreaks havoc.
